Simvastatin prevents dopaminergic neuronal injury in experimental PD models via activation of NF-kB and MMP 9 and 3 [ 2008 - 2009 ]

Also known as: Prevention on 6-OHDA or LPS-induced neuronal injury by delivery with simvastatin via anti-inflammatory mechanisms

Research Grant

[Cite as]

Researchers: Qing Wang (Principal investigator)

Brief description Increasing evidence shows that neuroinflammation may account for dopamine neuron death in Parkinson’s disease (PD). This work aims to provide systematic picture of inflammatory response in PD, and explore anti-inflammatory mechanisms of simvastatin on the progression of PD. We expect that the results may provide a therapeutic strategy using simvastatin via different methods of administration in treating PD, and provide new information about the anti-inflammatory roles of simvastatin.

Funding Amount $AUD 87,937.50

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF

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