Silent Mutations in the HIV-1 Reverse Transcriptase Selected during Antiretroviral Therapy [ 2010 - 2012 ]

Research Grant

Researchers: Prof Gilda Tachedjian (Principal investigator) ,  A/Pr Nicolas Sluis-Cremer ,  A/Pr Paul Harrigan ,  Dr Secondo Sonza

Brief description This project seeks to determine the role of silent mutations in the HIV reverse transcriptase that are selected during drug therapy in HIV infected individuals on HIV fitness, reverse transcriptase function and the emergence of drug resistance. This study will increase our understanding of the mechanisms by which the virus evades the effects of antiretrovirals and will provide a rationale for deciding on the best drug combinations for use in patients infected with specific HIV strains (clades).

Funding Amount $AUD 555,325.32

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant