Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/1139366]Researchers: A/Pr Stuart Brierley (Principal investigator) , A/Pr Grigori Rychkov , Dr Irina Vetter , Prof Richard Lewis
Brief description Patients with Irritable Bowel Syndrome suffer from chronic abdominal pain and co-morbidities such as over-active bladder. These symptoms arise from sensory nerve fibres in the colon and bladder that signal pain to innocuous stimuli. We are excited to report that a specific voltage-gated sodium channel, called NaV1.1, plays a key pathological role in generating these symptoms. Here, we will specifically target and block NaV1.1 expressing pain-sensing neurons, provide key advances for therapies.
Funding Amount $AUD 706,563.82
Funding Scheme Project Grants
Notes Standard Project Grant
- nhmrc : 1139366
- PURL : https://purl.org/au-research/grants/nhmrc/1139366