grant

Signalling through a bioactive aggrecan fragment: what is the mechanism? [ 2014 - 2016 ]

Also known as: Signalling through a bioactive aggrecan fragment

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1060222]

Researchers: Prof Amanda Fosang (Principal investigator)

Brief description Osteoarthritis (OA) affects approximately 20% of Australians. There are no therapies that modify the course of the disease and joint replacement surgery is expensive and invasive. We have discovered that a peptide product of cartilage breakdown (the 32mer) signals cartilage cells to mount an inflammatory and catabolic response. We will determine how the 32mer triggers this response, whether other joint cells are similarly activated and how it can be stopped, with the goal of pursuing new targets for therapy

Funding Amount $AUD 431,347.62

Funding Scheme Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857