Self Adjuvanting CTL-Based Influenza Vaccines for Human Use [ 2006 - 2007 ]

Research Grant

Researchers: Prof David Jackson (Principal investigator) ,  Dr Weiguang Zeng ,  Prof Lorena Brown

Brief description This project will generate novel vaccines that elicit cell-mediated immunity against influenza infection. The vaccines are totally synthetic and therefore not constrained by the limitations in manufacturing which currently confront egg-grown vaccines. These vaccines induce very strong immune responses because they target dendritic cells which are pivotal for induction of all immune responses. This targeting capability is due to a simple lipid molecule incorporated into the vaccine which is recognised by specific receptors on the surface of dendritic cells and also causes their maturation, a step which is essential for recognition by the immune system of potential pathogens. The technology to design and assemble these new vaccines is already.

Funding Amount $AUD 214,842.76

Funding Scheme NHMRC Strategic Awards

Notes Urgent Research - Pandemic Influenza - H5N1