Secreted exosome-like vesicles from the carcinogenic liver fluke [ 2015 - ]

Research Grant

Researchers: Prof Alexander Loukas (Principal investigator) ,  A/Pr Thewarach Laha ,  Dr JAVIER SOTILLO GALLEGO

Brief description Parasitic liver flukes secrete microscopic cell-like vesicles into the bile ducts when feeding on infected humans. These vesicles, called exosomes, are taken up by the cells lining the bile ducts and promote them to become pre-cancerous. We will characterise the contents of these fluke exosomes and identify the key molecules on their surfaces that can be used to prevent exosome uptake by cells and ultimately form the basis of a vaccine that prevents fluke infection and subsequent liver cancer.

Funding Amount $742,660.00

Funding Scheme Project Grants

Notes Standard Project Grant