Screening for Recently Defined Genetic Lesions in Poor Risk Adult and Childhood ALL, and Developing Treatment Approaches to Target Causative Pathways. [ 2013 - 2015 ]

Research Grant

Researchers: Prof Deborah White (Principal investigator) ,  A/Pr Rosemary Sutton ,  Prof Charles Mullighan ,  Prof Timothy Hughes

Brief description Most adults and 20% of children with ALL relapse and die of their disease. Chromosomal changes resulting in the formation of new proteins have been recently identified in a significant number of cases. Importantly, drugs targeting these proteins are in clinical practice for other diseases. We will develop new tests to rapidly identify these patients at diagnosis, and assess the efficacy of adding these drugs to first line treatment in a clinical trial. The outcome for these patients will likely improve significantly using this approach

Funding Amount $AUD 744,938.95

Funding Scheme Project Grants

Notes Standard Project Grant