Screening agents active against the late-stage inflammatory cytokines for activity against influenza disease [ 2006 - 2008 ]

Research Grant

Researchers: Prof Ian Clark (Principal investigator) ,  Arno Mullbacher ,  The Australian National University (Managed by)

Brief description Infection with a virulent influenza virus that the body has never encountered before, particularly H5N1, sends the immune system into overdrive, and causes a massive release of proteins (inflammatory cytokines), known as a cytokine storm, that in and of itself leads to death. The object of this research is to screen, in a mouse influenza model, agents known to prevent this occurring and antagonise it once it has occurred. This will be done with and without Tamiflu, a standard anti-influenza drug.

Funding Amount $AUD 241,409.42

Funding Scheme NHMRC Strategic Awards

Notes Urgent Research - Pandemic Influenza - H5N1