Scarring and angiogenesis in the airway wall in smoking and COPD: links between inflammation and remodelling [ 2008 - 2011 ]

Research Grant

Researchers: Prof Eugene Walters (Principal investigator) ,  A/Pr David Reid ,  Dr Adele Holloway ,  Dr Richard Wood-Baker ,  E/Pr H Muller

Brief description Smoking damages airways to produce scarring and new blood vessel growth resulting in airway narrowing, so-called COPD. Details of these processes are poorly understood. We will analyse airway biopsies taken from smokers, to dissect out the linkages between airway damage, airway inflammation, structural remodelling, and clinical changes. We will investigate the effects on these processes of: 1) inhaled corticosteroid; and 2) smoking cessation over 3 and 12 months.

Funding Amount $AUD 361,614.64

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant