Ryanodine receptor inhibitors as therapy for Ca2+ store overload induced arrhythmias [ 2011 - 2014 ]

Research Grant

Researchers: Prof Derek Laver (Principal investigator) ,  Prof Bjorn Knollmann ,  Prof Dirk Van Helden

Brief description This study investigates a new therapeutic action recently discovered for flecainide, an antiarrhythmic agent that we find to completely prevent and inherited form of stress-induced arrhythmias called CPVT. The findings will provide the first detailed mechanistic understanding of an antiarrhythmic drug, findings that will also give a new direction for drug design to control common arrhythmias such as occur in diseases such as coronary artery disease.

Funding Amount $AUD 555,892.81

Funding Scheme Project Grants

Notes Standard Project Grant