Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/1025088]Researchers: Prof Michael Waters (Principal investigator) , Dr Andrew Brooks
Brief description We have discovered that the cell surface receptor for growth hormone travels to the cell nucleus in dividing cells, including cancer cells. Given the role of growth hormone in promoting growth postnatally, we seek to uncover how the nuclear receptor promotes proliferation directly, and by gene splicing. We have identified strong candidates for its direct actions through proteomics, and a DNA binding site for the receptor. Here we will investigate its role in proliferation, gene splicing and DNA strand break repair after cell irradiation.
Funding Amount $AUD 429,387.56
Funding Scheme Project Grants
Notes Standard Project Grant
- nhmrc : 1025088
- PURL : https://purl.org/au-research/grants/nhmrc/1025088
