grant

Roles for MAPK-ERK1-2, -catenin-TCF and Smad3 mediated signalling pathways in TGF -induced cataract [ 2008 - 2010 ]

Also known as: TGF signalling in cataract development

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/512355]

Researchers: Prof Johnston Mcavoy (Principal investigator) ,  Prof Frank Lovicu

Brief description Posterior capsular opacification (PCO) is a common and costly complication of cataract surgery that is caused by aberrant growth of lens cells. The TGF growth factor family causes PCO. TGF activates three signalling pathways in the lens, MAPK-ERK1-2, -catenin-TCF and Smad3; however currently we do not know which one induces PCO. This project will identify the pathway(s) that prevent TGF from causing cataracts. This is critical for the development of pharmaceuticals to prevent PCO.

Funding Amount $AUD 339,071.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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321016 | Anterior subcapsular cataract | Cataract | Cell differentiation | Growth factor signalling | Lens pathology | Posterior capsular opacification | Secondary cataract | Transforming growth factor beta | Transgenic mice |
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