grant

Roles of integrin receptors and the Helicobacter pylori protein CagL in gastritis and gastric cancer [ 2009 - 2012 ]

Also known as: How does Helicobacter co-opt integrin receptor molecules on stomach cells to cause gastritis and gastric cancer?

Funded by National Health and Medical Research Council
Managed by Monash University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/545983]

Researchers: Dr Terry Kwok (Principal investigator)

Brief description How the bacterium Helicobacter pylori (Hp) causes gastritis and gastric cancer in the stomach is not well understood. Here we investigate the molecular languages used by Hp to deregulate the normal functions of the human stomach cells. The research outcomes will on one hand help us to better understand how Hp causes diseases, and on the other hand, facilitate the development of new antibiotics or treatment therapies to combat gastric cancers and gastritis.

Funding Amount $AUD 290,697.04

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
270199 | Acute gastritis and peptic ulcer | Chronic gastritis | Chronic inflammation caused by bacterial infections | Gastric adenocarcinoma | Molecular basis of Helicobacter-induced carcinogenesis | Mucosa-associated lymphoid tissue (MALT) lymphoma | Roles of integrins and their signalling in gastric diseases | Strcuture-function of bacterial virulence factors | The molecular basis of Helicobacter-host cell interactions | The molecular pathogenesis of Heliocbacter infections |
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