Role for zinc and ZIP2 in the action of nitric oxide and in vascular protection against cigarette smoke and cardiovascular disease [ 2018 - 2020 ]

Research Grant

Researchers: Dr Peter Zalewski (Principal investigator) ,  Dr Chiara Murgia ,  Dr Rosanna Tavella ,  Prof John Beltrame ,  Prof Sandra Hodge

Brief description The NO/cGMP signalling pathway, which is central to cardiovascular physiology and protection against disease, is only fully effective when there are adequate levels of zinc in the vascular endothelium. This is especially important where zinc stores are depleted (elderly, smokers, diabetics and kidney disease). There is an urgent clinical need to implement strategies to monitor vascular Zn status. This application will explore the underlying science and translate these to the clinic.

Funding Amount $AUD 695,543.77

Funding Scheme Project Grants

Notes Standard Project Grant