grant

The role and underlying mechanisms of constitutional epigenetic silencing in cancer predisposition [ 2011 - 2013 ]

Also known as: Distinct types of epimutations in cancer susceptibility

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1006498]

Researchers: Dr Megan Hitchins (Principal investigator)

Brief description Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.

Funding Amount $AUD 218,617.59

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF

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