THE ROLE OF UBIQUITIN LIGASE ADAPTOR PROTEIN NDFIP1 IN NEURONAL DEVELOPMENT [ 2011 - 2013 ]

Research Grant

Researchers: Dr Jenny Gunnersen (Principal investigator) ,  A/Pr Jason Howitt

Brief description Many brain diseases are characterized by faulty connections between nerve cells (neurons), in some cases caused by the inability to remove unwanted proteins from the neuron. This function is carried out by the ubiquitin-proteasome system (UPS). We have evidence that a UPS protein called Ndfip1 is important for forming functional brain circuits. We aim to discover whether neuron growth, branching and connectivity is promoted by Ndfip1 targeting of PTEN (phosphatase with tensin homology) to the UPS.

Funding Amount $AUD 581,813.44

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant