The role of TRPM2 channels in oxidative stress-induced liver damage [ 2015 - ]

Research Grant

Researchers: A/Pr Grigori Rychkov (Principal investigator) ,  Prof Alastair Burt ,  Prof Greg Barritt

Brief description Oxidative stress plays a central role in liver injury induced by drug toxicity, ischemia-reperfusion, non-alcoholic fatty liver disease and viral hepatitis. A hallmark feature of oxidative-stress mediated hepatocellular death is Ca2+ and Na+ overload which suggest activation of ion channels on the plasma membrane. This project will investigate the role of Transient Receptor Potential Melastatine 2 (TRPM2) non-selective channels in oxidative stress-induced hepatocellular death.

Funding Amount $558,433.00

Funding Scheme Project Grants

Notes Standard Project Grant