Role of Toll-like receptor 7 in rhinovirus-induced asthma exacerbation [ 2014 - 2017 ]

Research Grant

Researchers: Prof Joerg Mattes (Principal investigator) ,  Prof Paul Foster ,  Prof Peter Wark

Brief description One third of the annual asthma-related health care expenditure may be attributable to asthma-related hospitalisations. Even mild asthmatics experience severe exacerbations at a rate of almost one per year1 and those attacks can be fatal. Rhinovirus (RV) causes the majority of asthma exacerbations which may be linked to an impaired antiviral interferon (IFN) response in asthmatics. RV is sensed by Toll-like receptor (TLR) 7, but the role of this innate host defence pathway in regulating antiviral

Funding Amount $AUD 697,248.11

Funding Scheme Project Grants

Notes Standard Project Grant