Role of the tissue kallikrein-kinin system in abdominal aortic aneurysm formation and progression [ 2009 - 2011 ]

Research Grant

Researchers: Prof Jonathan Golledge (Principal investigator) ,  A/Pr Catherine Rush ,  A/Pr Lajos Gera ,  Prof Heinrich Korner ,  Prof Jurg Ott
View all 6 related researchers

Brief description Up to 5% of people over 60 years develop weakening of their aorta leading to slow dilation of the vessel, which may burst resulting in sudden death. The only treatment is surgery, which has complications and is unsuitable for some patients. Drugs which slow the disease would be invaluable. We have identified a role for kinins in aneurysms. We will investigate how these molecules contribute to aortic disease and if blocking them can be used as a basis for medical treatment of artery weakening.

Funding Amount $AUD 457,779.36

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant