grant

The role of the TGF-b superfamily cytokine MIC-1 in the pathogenesis of atherosclerosis [ 2004 - 2006 ]

Also known as: MIC-1 and atherosclerosis

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/300501]

Researchers: Prof Samuel Breit (Principal investigator)

Brief description MIC-1 is a protein first cloned and characterised by our research group. It belongs to the TGF beta protein superfamily which is very important in development, cancer, wound - fracture healing and inflammation. The aim of this project was to start to gain an understanding of the role of this protein, both in normal biological processes (especially pregnancy) and in disease. MIC-1 is present in the blood of all individuals and high levels are associated with an increased risk of heart attacks and strokes. In this study we wish to use animal models, in which the gene for MIC-1 has either been deleted or enhanced, to determine whether MIIC-1 plays a direct role in these diseases.

Funding Amount $AUD 348,950.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857