Role of SPPL2A on B cell survival and antibody production in mice and humans [ 2015 - ]

Research Grant

Researchers: A/Pr Anselm Enders (Principal investigator)

Brief description B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.

Funding Amount $569,859.00

Funding Scheme Project Grants

Notes Standard Project Grant