Role of sphingolipid signalling in hepatic insulin resistance and its application in prediction of risk for type 2 diabetes and prediabetes [ 2016 - 2020 ]

Research Grant

Researchers: Prof Mathew Vadas (Principal investigator) ,  Prof Geoffrey Mccaughan ,  Prof Jennifer Gamble ,  Prof Pu Xia

Brief description Type 2 diabetes is expected to reach epidemic proportions in the coming decades. Prediabetes is usually unrecognized and constitutes a major public health concern that needs earlier interventions, because the majority of prediabetic subjects proceed to T2D. We have identified an enzyme that plays an important role in insulin signalling. The possibility is that the level or activity of this enzyme is a potential biomarker of the prediabetes state and could be also used as a target

Funding Amount $AUD 582,338.81

Funding Scheme Targeted Calls

Notes NHMRC-NSFC Joint Call for research on Type 2 Diabetes