Role of SmcHD1 in X chromosome inactivation. [ 2008 - 2010 ]

Research Grant

Researchers: Dr Graham Kay (Principal investigator) ,  A/Pr Marnie Blewitt

Brief description Epigenetic modifications to the genome do not involve DNA sequence changes but modify gene expression during normal development. In diseases, like cancer, epigenetic modifications modulate gene expression in favour of disease progression. We will study the SmcHD1 gene that is involved in X chromosome inactivation, an epigenetic mechanism operating to ensure equal dosage of X-linked genes between males and females. This project will aid our understanding of chromosome structure and function.

Funding Amount $AUD 486,097.51

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant