The Role of Raptor and Rictor Signalling Pathways in Osteogenesis and Mesenchymal Stem Cell Fate Determination [ 2012 - 2014 ]

Research Grant

Researchers: Prof Andrew Zannettino (Principal investigator) ,  Dr Stephen Fitter ,  Prof Stan Gronthos

Brief description Skeletal diseases associated with excessive bone loss and skeletal fragility, such as osteoporosis, affect 2.2 million Australians and cost our health system approximately $7.4 billion per annum. Studies from our laboratory suggest a critical role for the mTOR signalling pathway in bone development. Using transgenic animals and state-of-the-art techniques, we will investigate the role of mTOR in pre- and post-natal skeletal development. Results from these studies may provide novel approaches to treat age-related bone loss syndromes.

Funding Amount $AUD 562,742.09

Funding Scheme Project Grants

Notes Standard Project Grant