Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/124411]Researchers: Prof Phillip Bird (Principal investigator)
Brief description Cytotoxic lymphocytes eliminate virus-infected or cancerous cells from the body. This is achieved by the release of powerful cytotoxins that kill the abnormal cell. Unless carefully targeted these cytotoxins can damage surrounding normal tissue or the cytotoxic lymphocyte itself, and lead to autoimmune disease. One of the most important cytotoxins is a protease called granzyme B. We have discovered a natural inhibitor of granzyme B that is present in cytotoxic cells and testis. Our studies are aimed at understanding the role of the inhibitor in human immune and reproductive function. We will also design and evaluate synthetic compounds based on the natural inhibitor that will enable us to easily measure granzyme B levels and control its activity.
Funding Amount $AUD 820,136.42
Funding Scheme NHMRC Project Grants
Notes Standard Project with Research Fellowship
- nhmrc : 124411
- PURL : https://purl.org/au-research/grants/nhmrc/124411
