The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease [ 2014 - 2017 ]

Research Grant

[Cite as]

Researchers: A/Pr Giuseppe Verdile (Principal investigator) ,  A/Pr Michael Lardelli Dr Matthew Sharman

Brief description The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer's disease. We have discovered that a shortened form of Presenilin protein, "PS2V", appears to increase specifically the rate at which the APP protein is cleaved to produce the "Amyloid beta" protein fragment that is found in Alzheimer's disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for the disease.

Funding Amount $AUD 552,741.24

Funding Scheme Project Grants

Notes Standard Project Grant

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