grant

Role of plasmepsin V and PTEX complex in Plasmodium liver infection [ 2018 - 2020 ]

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1139153]

Researchers: A/Pr Justin Boddey (Principal investigator) ,  Prof Tania De Koning-Ward Dr Kelly Rogers

Brief description Plasmepsin V and PTEX are essential proteins for malaria parasites to grow inside red blood cells. These proteins control the export of parasite proteins into red cells, causing disease. Before red blood cells are infected, parasites invade liver cells. Plasmepsin V and PTEX are expressed during liver infection but their function is currently unknown. We hypothesise that they allow parasites to export proteins into liver cells in order to survive and, thus, are antimalarial drug targets.

Funding Amount $AUD 860,286.12

Funding Scheme Project Grants

Notes Standard Project Grant

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