grant

The role of phosphorylation and signalling for invasion of Plasmodium falciparum into human erythrocytes. [ 2012 - 2015 ]

Also known as: Unravelling the sequence of signals required for invasion of the malaria parasite Plasmodium falciparum: identifying new targets to stop an old foe in its tracks.

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1035715]

Researchers: Dr Danny Wilson (Principal investigator)

Brief description The intracellular signals that govern Plasmodium falciparum malaria invasion of the red blood cell are poorly understood. It is likely calcium dependent phosphorylation leads to recruitment and activation of a cascade of proteins. This study combines a break-through in purification of viable P. falciparum merozoites with proteomic analysis of phosphorylation states to assess intracellular signalling. It is expected the processes identified will be unique to P. falciparum and targetable by drugs.

Funding Amount $AUD 307,946.17

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF

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