Role of oxidative stress in activating ATM to protect against neurodegeneration [ 2012 - 2014 ]

Research Grant

Researchers: Prof Martin Lavin (Principal investigator) ,  Dr Mark Graham ,  Dr Sergei Kozlov

Brief description ATM is the protein defective in the human genetic disorder ataxia-telangiectasia (A-T). This project is designed to investigate how this protein is activated by oxidative stress. The study is largely a mechanistic one, to investigate changes occurring in ATM as part of the activation process. There is evidence that ATM exists in the cytoplasm in neuronal cells and understanding its function in these cells may assist in understanding the basis for neurodegeneration in A-T.

Funding Amount $AUD 570,334.32

Funding Scheme Project Grants

Notes Standard Project Grant