Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/157989]Researchers: Dr Sharon Byers (Principal investigator)
Brief description The degradation of complex carbohydrate structures occurs within specialised intracellular organelles (lysosomes). Their degradation occurs in a strictly defined sequence involving initial clipping into intermediate sized fragments which are each then degraded piece by piece from one end. In this proposal we seek to understand the role of a newly defined enzyme in the initial clipping process. This information will aid our understanding of skeletal pathology in a group of genetic disorders in which complex carbohydrate degradation is impaired. In addition due to the widespread location of complex carbohydrates and their fundamental roles in tissue development and growth, the project has wider implications in diverse disease states such as cancer and wound repair.
Funding Amount $AUD 256,527.54
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 157989
- PURL : https://purl.org/au-research/grants/nhmrc/157989
