The role of Notch signalling in muscular dystrophy [ 2009 - 2012 ]

Research Grant

Researchers: Prof Gordon Lynch (Principal investigator) ,  Prof Aaron Russell

Brief description Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, caused by a lack of a protein called dystrophin. Dystrophic muscles are fragile, prone to injury, and have a compromised ability to regenerate after damage. Defective Notch signalling has been implicated in the poor regenerative response of aged muscles and similarly in dystrophy based on our preliminary data. Modulating Notch signalling could therefore delay the onset or slow the progression of DMD.

Funding Amount $AUD 526,878.44

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant