The role of non-classical MHC class I molecules in adaptive immunity [ 2009 - 2015 ]

Research Grant

Researchers: Dr Lucy Sullivan (Principal investigator)

Brief description Specialised proteins called MHC class Ia molecules (MHC-Ia) stimulate killer T cells to lyse virus infected cells. In contrast, the function of the closely related MHC-Ib is uncertain. Recent findings have demonstrated that MHC-Ib can also be recognised by T cells and this interaction is important in the control of viral infections. However, despite the similarity to MHC-Ia, it is unclear how this interaction occurs. This project aims to investigate how killer T cells recognise MHC-Ib molecules.

Funding Amount $AUD 443,834.86

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF