The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease [ 2014 - 2016 ]

Research Grant

Researchers: A/Pr Mark Bellingham (Principal investigator) ,  A/Pr Ann Turnley ,  A/Pr Peter Noakes

Brief description Using mice with mutant genes causing amyotrophic lateral sclerosis, we will test whether motor neuron hyper-excitability during early development causes excessive synapse and dendrite formation, ultimately leading to neuronal death. We will also test whether activity-dependent secretion of neurotrophic factors and activation of their receptors plays a role in this disease. This will show whether neuronal hyper-activity and neurotrophic factor signaling plays a causal role in this disease.

Funding Amount $AUD 700,330.97

Funding Scheme Project Grants

Notes Standard Project Grant