grant

The Role of Med12, a subunit of RNA polymerase II mediator, in haemopoiesis [ 2008 - 2011 ]

Also known as: The role of a transcription factor in blood development

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/516750]

Researchers: Dr Judith Layton (Principal investigator) ,  Prof Graham Lieschke (Principal investigator)

Brief description In a screen of zebrafish for mutations in blood cell development, we isolated a mutant called syrah. The mutation causing the blood defect was identified in a gene called med12, which encodes a component of the RNA transcription machinery in cells. To understand how this mutation causes a reduction in blood cells, we will identify the proteins that interact with the med12 protein. Understanding the pathway involved may lead to the discovery of new causes of human congenital blood diseases.

Funding Amount $AUD 495,490.28

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857