The role of MBOAT7 in hepatic inflammation: implications for therapy [ 2018 - ]

Research Grant

Researchers: Prof Christopher Liddle (Principal investigator) ,  A/Pr Leon Adams ,  Dr Mohammed Eslam ,  Prof Thomas Berg

Brief description When a fatty liver progresses to develop inflammation, patients are at-risk of liver-related morbidity and death. Currently, there are no effective therapies. From human studies, we have discovered that a lipid modifying enzyme (MBOAT7) profoundly regulates liver inflammation. In this proposal, we will obtain a detailed understanding of how the activity of this pathway modulates inflammation. We expect to show that MBOAT7 is a novel ‘druggable’ pathway for the treatment of liver inflammation.

Funding Amount $848,340.00

Funding Scheme Project Grants

Notes Standard Project Grant