Role of MACROD2 Loss in DNA Repair, Chromosomal Instability and Development of Colorectal Cancer: Clinical and Therapeutic Implications [ 2015 - 2017 ]

Research Grant

Researchers: A/Pr Oliver Sieber (Principal investigator) ,  A/Pr Ian Street ,  Dr Jayesh Desai ,  Dr Michael Buchert

Brief description The MACROD2 gene is deleted in one-third of human bowel cancers. We have discovered that MACROD2 deletion causes defective DNA repair and tumour chromosomal instability. Here, we will use novel laboratory models to show that MACROD2 loss actively promotes bowel cancer development. We will test the clinical implication of MACROD2 loss for predicting tumour therapy response and will investigate the potential of exploiting this deficiency for drug targeting.

Funding Amount $AUD 772,871.33

Funding Scheme Project Grants

Notes Standard Project Grant