Role of load detection and compensation in pathogenesis of obstructive sleep apnea. [ 2007 - 2010 ]

Research Grant

Researchers: Dr Fergal O'Donoghue (Principal investigator) ,  A/Pr Kate Webster ,  Mr Peter Rochford ,  Prof Robert Pierce

Brief description This proposal will use novel techniques to explore how defective responses to the threat posed by a collapsing upper airway contribute to the Obstructive Sleep Apnea syndrome, a disease involving repetitive collapse of the upper airway in sleep. Responses to small increases in the resistance to inspiratory airflow will be examined by measuring the small electrcal responses in the brain to these loads, and the response of the muscles responsible for maintaining airway patency to the collapsing forces induced by these loads, in both wakefulness and sleep. The brain's response to resistive loads will also be evaluated using the techique of functional magnetic resonance imaging, which demonstrates areas of the brain activated by a stimulus.

Funding Amount $AUD 340,867.13

Funding Scheme Project Grants

Notes Standard Project Grant