Role of lncRNA IDH1-AS1 in regulating c-Myc driven-glycolysis and tumorigenesis [ 2018 - 2020 ]

Research Grant

Researchers: Prof Xu Dong Zhang (Principal investigator) ,  A/Pr Tao Liu ,  Prof Rodney Scott

Brief description It is thought that understanding cancer metabolism will reveal vulnerabilities that can be exploited in the clinic. Indeed, compared to most normal cells, cancer cells utilise different fuels to sustain proliferation and to adapt to their environment. Herein we have discovered a molecular switch that regulates the key metabolic enzyme IDH1 and show this controls tumour growth. Given this switch may be active in 50% of cancers we anticipate our work will have significance to many cancer types.

Funding Amount $AUD 685,043.19

Funding Scheme Project Grants

Notes Standard Project Grant