Role of islet ?-cell failure in the pathogenesis of non-alcoholic steatohepatitis [ 2012 - 2014 ]

Research Grant

Researchers: Prof Christopher Nolan (Principal investigator) ,  Prof Geoffrey Farrell ,  The Australian National University (Managed by)

Brief description Some people respond to obesity poorly developing diseases such as non-alcoholic steatohepatitis (NASH) and diabetes. Other people do not, safely storing the excess energy in non-abdominal fat. The applicants will study 2 obese strains of mice; one develops “adipose tissue restriction”, NASH and diabetes, the other does not. The hypothesis that failure of compensatory insulin secretion to over-nutrition is an upstream event causing adipose tissue restriction, followed by NASH, will be tested.

Funding Amount $AUD 560,111.50

Funding Scheme Project Grants

Notes Standard Project Grant