grant

The role of interleukin (IL)-27 in the endogenous anti-tumour immune response and the use of an IL-27 agonist as a cancer therapeutic. [ 2013 - 2015 ]

Also known as: The role of immune signalling molecule, interleukin 27, in protective anti-cancer immune responses and its potential use as a therapeutic.

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1044967]

Researchers: Dr Marcel Batten (Principal investigator) ,  A/Pr Alexander Swarbrick A/Pr Daniel Christ

Brief description Our data in mice suggest that immune cell signalling protein, interleukin (IL)-27, enhances anti-tumour immune responses and slows growth of mammary tumours and carcinogen induced sarcomas. This project aims to test how IL-27 promotes protective anti-tumour immune responses and to develop a modified IL-27 protein that will be tested as a cancer therapeutic in mice. This will be the first study to examine IL-27 function using physiological tumour models and may provide proof of concept for a new therapeutic strategy for some human cancers.

Funding Amount $AUD 473,960.63

Funding Scheme Project Grants

Notes Standard Project Grant

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