The role of innate immunity genes in COPD [ 2006 - 2008 ]

Research Grant

Researchers: Prof Ian Yang (Principal investigator) ,  A/Pr Paul Zimmerman ,  Dr Maria Nataatmadja ,  Prof Kwun Fong

Brief description Chronic obstructive pulmonary disease (COPD) is a smoking-induced lung disease that is the fourth leading cause of death in Australia. The immune system is highly likely to play an important role in the progression of this condition, because of the frequency of respiratory infections that occur. We will examine in detail the immune response of COPD patients, examining specific genes and proteins that are important in the defence against bacteria. Blood samples will be obtained from people with COPD who are stable. We will then obtain further blood samples when there is a flare-up of the lung condition, and during recovery. We will compare the results from the blood samples, with variations in the genes that people carry. Information about individual differences in the body's response to infection would help us to better understand how COPD develops, and to initiate research on new methods of diagnosis and treatment of COPD.

Funding Amount $AUD 353,136.74

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant