The role and inheritance of constitutional epimutations in early-onset colorectal cancer. [ 2009 - 2012 ]

Research Grant

Researchers: Dr Megan Hitchins (Principal investigator) ,  Prof Nicholas Hawkins ,  Prof Robyn Ward

Brief description Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.

Funding Amount $AUD 347,551.54

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant