Role of Immediate early gene induction and AP-1 activation in HDAC inhibitor induced apoptosis. [ 2011 - 2013 ]

Research Grant

Researchers: Prof John Mariadason (Principal investigator) ,  Dr Amardeep Dhillon

Brief description Histone deacetylase inhibitors (HDACi) are a novel class of anti-tumor agents, recently approved for the treatment of cutaneous T-cell lymphoma. The goal of this study is to improve our understanding of how this class of drug induces tumor cell death. These studies are designed to provide insight into which patients are most likely to benefit from treatment with these agents. Second, they will provide direction into how the therapeutic efficacy of HDACi may be enhanced, through combination with other existing therapeutics.

Funding Amount $AUD 524,820.33

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant