The role of IL-17 in regulating liver macrophage permissiveness for Leishmania infection [ 2016 - ]

Research Grant

Researchers: Dr Lynette Beattie (Principal investigator) ,  Dr Geoffrey Gobert

Brief description Visceral Leishmaniasis is a disease of poverty in the developing world caused by Leishmania parasites, which live and replicate within host tissue macrophages. A cytokine produced by host cells, IL-17A impairs the ability of liver macrophages to control this infection, as mice that lack IL-17A have lower parasite burdens in the liver after experimental infection. We propose to investigate if IL-17A mediates this impaired control by tuning the permissiveness of host macrophages to infection.

Funding Amount $655,082.00

Funding Scheme Project Grants

Notes Standard Project Grant