The role of HLH genes in hemopoietic development [ 2000 - 2002 ]

Research Grant

Researchers: Glenn Begley (Principal investigator) ,  Dr Johanna Van Eekelen

Brief description We want to understand more about the control of blood cell formation and the development of leukemia. We have discovered one gene that is very important in both these processes. It is the most common genetic abnormality involved in causing human T-cell leukemia, and we have recently shown that it is absolutely required for the development of all blood cells within an animal. We wish to take these observations further so that we can ultimately understand how a gene important in blood cell formation can also be important in causing leukemia. Here we propose to use genetic engineering approaches to generate mice in which the function of this gene is ablated or removed in a controlled and regulated fashion.

Funding Amount $AUD 396,572.40

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant