Role of the histone variant H3.3 in germ cell development [ 2011 - 2013 ]

Research Grant

Researchers: Dr Jeffrey Mann (Principal investigator) ,  A/Pr Lee Wong

Brief description Over their life cycle, germ cells are unique in undergoing a large scale reformatting of their gene or DNA control systems, required for their own development, and for the development of the fertilized egg. We think that the protein ïhistone H3.3Í is crucial to this reformatting process. We will test this possibility by determining how much H3.3 is present in germ cells. Also, we will make mice which lack this protein in germ cells to see if this affects the reformatting process.

Funding Amount $AUD 581,223.41

Funding Scheme Project Grants

Notes Standard Project Grant