Role of heparan sulfate, heparanase inhibitors in the development and prevention of type 1 diabetes [ 2008 - 2013 ]

Research Grant

Researchers: Prof Christopher Parish (Principal investigator) ,  A/Pr Charmaine Simeonovic ,  Dr Craig Freeman ,  Prof Gerard Hoyne ,  The Australian National University (Managed by)

Brief description Our recent studies have shown that a special protein (an enzyme called heparanase) and the special carbohydrate (heparan sulfate or HS) that it degrades, play a previously unrecognised role in the development of Type I diabetes (T1D) in mice. We will explore whether destructive immune cells use heparanase to damage insulin-producing islets and deplete them of HS, resulting in islet cell death and T1D. We will develop new agents to inhibit this damage, prevent T1D and protect islet transplants.

Funding Amount $AUD 3,242,771.90

Funding Scheme NHMRC Strategic Awards

Notes Diabetes Collaborative Research Grants