The role of glutathionylation in redox modification of L-type Ca2+ channel function during oxidative stress in the heart [ 2008 - 2010 ]

Also known as: Determining how the cardiac L-type calcium channel protein is modified by free radicals

Research Grant

[Cite as]

Researchers: A/Pr Livia Hool (Principal investigator) ,  A/Pr Ben Corry A/Pr John Alvarez Dr Peter Arthur

Brief description The L-type calcium channel is a protein in the membrane of heart muscle cells responsible for regulating the entry of calcium into cells and maintaining normal heart rhythm and contraction. We have shown that reactive oxygen species can regulate the function of the calcium channel. We are now interested in determining whether a direct modification of the channel protein known as glutathionylation is responsible for altered channel function during oxidative stress such as after a heart attack.

Funding Amount $AUD 402,898.67

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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