Research Grant
[Cite as http://purl.org/au-research/grants/nhmrc/1004602]Researchers: Prof Richard Lewis (Principal investigator) , Prof Walter Thomas
Brief description Most modern drugs act on a class of cellular proteins known as GPCRs. Despite their importance, little is known about how agonists acting from the outside of cells produce a change in GPCR structure allowing signalling to the cell's interior. We have identified new residues on the extracellular surface of the alpha1 adrenoceptor that dramatically affect agonist responses, opening the door to understanding the molecular process of GPCR activation and the development of drugs that can target different GPCR conformations.
Funding Amount $AUD 414,786.47
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/1004602
- nhmrc : 1004602