Role of Erg in B-cell Acute Lymphoblastic Leukaemia [ 2017 - 2019 ]

Research Grant

Researchers: Prof Warren Alexander (Principal investigator) ,  Dr Ashley Ng ,  Dr Ian Majewski

Brief description Acute lymphoblastic leukaemia (ALL) is a lethal blood cancer for which current treatments are suboptimal. Over-expression of the ERG gene has been associated with the poor prognosis B cell ALL called Ph+ B-ALL. We have recently shown that loss of Erg prevents disease development in disease models. We hypothesise that expression of ERG is a key driver of Ph+ B-ALL and propose to define this role and identify new opportunities for development of specific novel therapeutics.

Funding Amount $AUD 766,751.29

Funding Scheme Project Grants

Notes Standard Project Grant